From its beginnings in the 1960s to the present day, OSC's leaders have undeniably been leaders in the field.
- Aden B. Meinel
Founding director of the Optical Sciences Center
1964-1973 - Peter A. Franken
Director of the Optical Sciences Center
1973-1983 - Harrison H. Barrett
Interim Director of the Optical Sciences Center
1983 - Robert R. Shannon
Director of the Optical Sciences Center
1983-1992 - Richard C. Powell
Director of the Optical Sciences Center
1992-1998 - James C. Wyant
Director of the Optical Sciences Center
1999-2005
Founding dean of the College of Optical Sciences
2005-2012 - Thomas L. Koch
Dean of the College of Optical Sciences
2012-present