OSC Colloquium: Roarke Horstmeyer, "Computational 3D Video Microscopy Using Dense Camera Arrays"

April 25, 2024
Roarke Horstmeyer

Optical Engineering

Horstmeyer Colloquium

Title

Computational 3D Video Microscopy Using Dense Camera Arrays

Abstract

We have developed a new type of computational microscope that uses a compact array of "micro-cameras" to jointly record high-resolution video across large areas. We refer to these novel systems as “multi-camera array microscopes” (MCAMs), which contain up to 96 individual synchronized image sensors and associated lenses to produce gigapixel-scale snapshot measurements. Co-designed software for image stitching, 3D image formation, and object tracking opens up a variety of new applications at the mesoscopic scale. Here, we detail a number of MCAM use cases, including for 3D video of dynamic specimens across large areas at near-cellular resolution, for rapid 3D screening of large collections of organoids, and for high-speed tomographic video  capture of freely moving organisms. 

Bio

Roarke Horstmeyer is an Assistant Professor of Biomedical Engineering at Duke University, and serves as the Scientific Director at Ramona Optics. He develops microscopes, cameras and computer algorithms for a wide range of applications, from forming large-area, high-resolution 3D videos of freely moving organisms to detecting blood flow and brain activity deep within tissue. Before joining Duke in 2018, Dr. Horstmeyer was a visiting professor at the University of Erlangen in Germany and an Einstein International Postdoctoral Fellow at Charité Medical School in Berlin. Prior to his time in Germany, Dr. Horstmeyer earned a PhD from Caltech’s EE department (2016), an MS from the MIT Media Lab (2011), and bachelor’s degrees in Physics and Japanese from Duke in 2006.

Contact

Florian Willomitzer, Colloquium Chair & Professor: colloquium@optics.arizona.edu

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Donna Strickland Colloquium
OSC Colloquium: Donna Strickland, "High Intensity Fiber lasers for Nonlinear Optics"
3:30 – 5 p.m., Dec. 5, 2024

Ti:sapphire lasers offer the largest bandwidths and therefore the shortest pulses.   The highest laser intensities have been achieved using Chirped Pulse Amplification (CPA) of large diameter solid state lasers.  CPA was needed to avoid damage from the nonlinear process of self-focusing.  The disadvantage of solid-state lasers is the limited average power.  On the other hand, diode pumped fiber laser systems offer significantly higher average power than solid state lasers. Self-focusing is eliminated in single mode fibers by guiding and so nonlinear optics can be beneficial rather than detrimental and used to broaden the gain bandwidth.  Single fiber laser amplifiers will not reach the highest intensities offered by solid state lasers, but in this talk, I will discuss developing fiber laser amplifiers for nonlinear optical interactions such as mid-infrared generation and laser acceleration of electrons that require high intensity and benefit from high average power.

Past Speakers

Hendra Nurdin
3:30 – 5 p.m., Nov. 21, 2024

OSC Colloquium: Hendra Nurdin, "Physical Learning Machines: Classical and Quantum Reservoir Computers and Beyond"

This colloquium will give a brief introduction to reservoir computing, an overview of its theoretical foundations, including the notion of a universal family of reservoir computers that is capable of approximating a certain family of nonlinear maps from input sequences to output sequences, as well as its inherent limitations. It will then motivate and touch on efforts by the speaker and his collaborators to exploit noisy near-term quantum computers as quantum reservoir computers. Finally, the colloquium will conclude with a discussion of research directions for further development of quantum reservoir computers as well as research trends in the broader recent efforts on engineered physical learning machines going beyond reservoir computers.
caleb baker colloquium
3:30 – 5 p.m., Nov. 7, 2024

OSC Colloquium: Caleb Baker, "Doing it for the 'Graph (Design, Function, and System Test Results of the Roman Coronagraph Instrument)"

As the Nancy Grace Roman Space Telescope approaches its planned launch date in 2027, the engineers of one of its two instruments have recent cause to celebrate. Roman’s Coronagraph Instrument (CGI), a technology demonstration chasing direct images of Jupiter-like exoplanets, completed its system-level thermal vacuum test in May 2024, successfully demonstrating that it performs to its threshold requirements in a flight-like environment. Please join me as we walk through the design, function, and performance demonstration of one of the most complex optical instruments NASA has ever attempted to fly.