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Title
Imaging Mueller Polarimetry for Biomedical Diagnostics from Micro- to Macroscale
Abstract
Recent advances in biophotonics are reshaping modern medicine by expanding the toolkit available to medical doctors for the screening, prevention, and treatment of serious health conditions. These developments are driven by the growing need for affordable and reliable optical diagnostic modalities. Imaging Mueller polarimetry has already demonstrated its potential as an accurate, non-contact, and cost-effective technique for optical biopsy of tissue in a number of fields, including gastroenterology, gynecology, neurosurgery, and digital histology. Polarized light is highly sensitive to the microstructure of biological tissues, which can be altered by pathological transformations. As a result, the contrast between healthy and diseased tissue regions is often significantly enhanced in the polarimetric images compared to conventional unpolarized intensity images. While Mueller microscopy facilitates pathology grading in the histological analysis of tissue thin sections, wide-field imaging Mueller polarimetry enables the delineation of pathological regions for the diagnostic and surgical guidance. Our results from ongoing preclinical studies using imaging Mueller polarimetry will be presented, along with a discussion of the prospects for developing next-generation polarimetric systems aimed at translating Mueller matrix imaging modalities into clinical practice.
Bio
Dr. Tatiana Novikova leads the group of Applied Optics and Polarimetry at the Laboratory of Physics of Interfaces and Thin Films of CNRS, Ecole polytechnique, Institut Polytechnique de Paris, Palaiseau, France. She is also a Courtesy Professor at the Department of Biomedical Engineering, Florida International University, Miami, FL, USA. Dr. Novikova obtained MSc degree in applied mathematics from the Moscow State University (Russia), PhD in applied mathematics and physics from the Moscow Institute of Mathematical Modelling (Russia), and Habilitation in Physics from the University Paris-Sud (France). Her research interests and area of expertise include optical polarization, Mueller polarimetry, biomedical imaging, polarimetric instrumentation, optical metrology and computational modeling of electromagnetic wave interaction with structured and random media. Dr. Novikova is a member of Editorial Board of the Journal of Biomedical Optics, co-Editor (with J. C. Ramella-Roman) of the book “Polarized Light in Biomedical Imaging and Sensing - Clinical and Pre-Clinical Applications” (Springer Cham, 2023), Fellow of SPIE and OPTICA, and the recipient of 2020 SPIE G. G. Stokes Award in optical polarization.
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